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Tracing developmental lineages

Dr. Bushra Raj, from the Perelman School of Medicine at the University of Pennsylvania, published an article in Nature Methods discussing how recent advancements in lineage tracing methods are enabling new insight into cell fate and trajectory during development. CRISPR–Cas9-based lineage analysis methods, imaging-based lineage analysis methods, and computational strategies are producing major impacts answering … Continue reading Tracing developmental lineages

IRM Awards 3rd Elaine Redding Brinster Prize to Stuart Orkin, MD

Recognized for landmark discoveries of the molecular basis of blood disorders and using the basic science findings for therapeutic approaches, the Institute for Regenerative Medicine at the University of Pennsylvania has awarded Stuart H. Orkin, MD the third Elaine Redding Brinster Prize in Science or Medicine. He elucidated the mechanism controlling the switch from fetal to adult hemoglobin, … Continue reading IRM Awards 3rd Elaine Redding Brinster Prize to Stuart Orkin, MD

Andrew Modzelewski, PhD: recipient 2023 Arnold and Mabel Beckman Foundation Award

Congratulations to IRM faculty, Andrew Modzelewski, PhD for being an award recipient as part of the 2023 Beckman Young Investigator Program. The Beckman Young Investigator (BYI) Program provides research support to the most promising young faculty members in the early stages of their academic careers in the chemical and life sciences, particularly to foster the … Continue reading Andrew Modzelewski, PhD: recipient 2023 Arnold and Mabel Beckman Foundation Award

Experimenting with stem cells at the bench

Working to find cellular cures for diseases.

The IRM supports initiatives to translate discoveries in stem cell science into new therapies. We offer:

  • Collaborative Research Programs
  • Grants for Innovative Ideas
  • Engaging Symposiums & Events
  • Training Workshops
  • Award-winning Outreach Partnerships
  • Scientific Communication Support

Research Programs

Epithelial Stem Cells

Program Leaders George Cotsarelis, MD cotsarel@pennmedicine.upenn.edu Pantelis Rompolas, PhD rompolas@pennmedicine.upenn.edu The cells that constitute our skin and line our organs are the first line of defense against injury and illness. These vital barriers are replenished by epithelial stem cells. IRM researchers study epithelial stem cells throughout the body to find ways to improve wound healing, heal the lungs after viral infection, reverse baldness, and … Continue reading Epithelial Stem Cells

Hematopoietic Stem Cells

Program Leaders Wei Tong, PhD tongw@chop.edu Ivan Maillard, MD, PhD imaillar@pennmedicine.upenn.edu Humans produce hundreds of billions of blood cells every day, thanks to the incredible regenerative potential of hematopoietic stem cells (HSCs). To create all those oxygen-carrying red blood cells and pathogen-fighting white blood cells, HSCs follow very specific development pathways. IRM researchers are exploring … Continue reading Hematopoietic Stem Cells

Neurodevelopment & Regeneration

Program Leaders Hongjun Song, PhD shongjun@pennmedicine.upenn.edu Frances Jensen, MD, FACP frances.jensen@uphs.upenn.edu The nervous system’s capacity for growth and change underlies everything from proper mental development to the body’s coordination and movement. IRM researchers study how neurons develop in different stages of life, why the neurons in limbs regenerate better than in the brain, and how … Continue reading Neurodevelopment & Regeneration

Reproductive Medicine

Program Leaders Kotaro Sasaki, MD, PhD ksasaki@upenn.edu Nicolas Plachta, PhD Nicolas.Plachta@pennmedicine.upenn.edu Kathleen O'Neill, MD kathleen.o'neill2@pennmedicine.upenn.edu The Program in Human Development and Reproduction focuses on the establishment of innovative approaches to study the key processes needed for the production of healthy offspring. The Program nucleates a multidisciplinary group of scientists uniquely poised to impact basic and … Continue reading Reproductive Medicine

Outreach

Sharing our science across the Philadelphia region and beyond.