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18Jun

Paper published on Krt15+ crypt cells

Véronique Giroux, first author and a postdoctoral researcher in Dr. Anil Rustgi’s lab at the University of Pennsylvania, collaborated with researchers from Fox Chase Cancer Center, and CHOP and published a paper on mouse intestinal Krt15+ crypt cells in Stem Cell Reports.

Highlights from the paper include:

Krt15 marks multipotent and self-renewing crypt cells in the mouse small intestine
Krt15+ crypt cells are radio-resistant and contribute to regeneration following injury
Apc loss in Krt15+ cells leads to intestinal adenoma and adenocarcinoma formation
Krt15+ cells may function as a cell of origin in intestinal cancer

*Krt15+* cells were visualized by GFP immunofluorescence (n = 4–7 mice/time point).

Véronique Giroux, Julien Stephan, Priya Chatterji, Ben Rhoades, E. Paul Wileyto, Andres J. Klein-Szanto, Christopher J. Lengner, Kathryn E. Hamilton, Anil K. Rustgi. “Mouse Intestinal Krt15+ Crypt Cells Are Radio-Resistant and Tumor Initiating.” Stem Cell Reports, May 24, 2018.

4May

pendari Events, Featured Stories, News

IRM Co-hosts Business of Regenerative Medicine Conference, July 17-18, 2018

The 11th annual Business of Regenerative Medicine: Innovation, Clinical Translation, and Entrepreneurship Symposium, is a 2-day event that will include lectures delivered by established entrepreneurs, industry and scientific leaders, panel discussions, networking events, and more. It is attended by entrepreneurs, junior and senior scientists, business executives, investors and analysts, technology transfer and development personnel, managers in the government, non-profit and profit sectors.

The Symposium is hosted by the Center for Cellular Immunotherapies and the Institute for Regenerative Medicine at the University of Pennsylvania in partnership with Case Western Reserve University, the Harvard Stem Cell Institute, the Parker H. Petit for Institute Bioengineering and Bioscience at Georgia Tech, and the Centre for Commercialization of Regenerative Medicine.

Click here for more information and to register.

4May

pendari Featured Stories, News

Study Published on the Intestinal Stem Cell Niche

Researchers from the University of Pennsylvania and the Weizmann Institute of Science have published a study on the intestinal stem cell niche in Nature. According to the study, the researchers have identified “subepithelial telocytes as an important source of Wnt proteins, without which intestinal stem cells cannot proliferate and support epithelial renewal.”

**FOXL1+ cells are telocytes and co-express PDGFRα.** Confocal imaging of cleared whole small intestine showing expression of PDGFRα (green) and EPCAM (red). Experiments were repeated at least three times with similar results. Scale bars, 10 µm.

Shoshkes-Carmel, Michal, Yue J. Wang, Kirk J. Wangensteen, Beáta Tóth, Ayano Kondo, Efi E. Massassa, Shalev Itzkovitz, and Klaus H. Kaestner. “Subepithelial Telocytes Are an Important Source of Wnts That Supports Intestinal Crypts.” Nature, May 2, 2018.

4May

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Penn Vet Researcher Publishes Paper on the Relationship between Calorie Restriction and Intestinal Regeneration

When mice were allowed to eat without limit and were then exposed to radiation, their intestinal cells’ (in red) regeneration was limited (left). Mice fed a calorie-restricted diet showed a greatly enhanced regenerative capacity in their intestinal tissue (right).

Christopher Lengner, Ph.D., associate professor in Penn’s School of Veterinary Medicine, along with lead author Maryam Yousefi (Penn graduate student) and researchers from Penn and China Agricultural University, has published a paper in Stem Cell Reports. Building on research that shows that animals fed calorie-restricted diets exhibit a better ability to regenerate tissue after injury, these researchers focused their work on finding the stem cell responsible for tissue regeneration in the intestines after the calorie-restricted subject (a mouse) had undergone radiation; they have pinpointed the particular stem cell as the reserve stem cell.

For more information on the research and its findings, please read Katherine Unger Baillie’s press release.

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