The 2020 IRM ISSCR Viewer Guide

Take an IRM-guided tour of this week’s meeting with our ISSCR viewer guide.

For the first time ever, the International Society for Stem Cell Research (ISSCR) Annual Meeting will be held virtually, from June 23 to June 27. This year, physical movement and jet lag won’t limit your ability to catch talks and meet new people. However, with so much great stuff happening over the next few days, it’s easy to feel overwhelmed.

Let us help you with that. Below is an “ISSCR viewer guide” featuring talks and posters from University of Pennsylvania and Children’s Hospital of Philadelphia (CHOP) researchers.

PRO TIP: While this guide sorts everything by day and time (Eastern Daylight Time for Philly folks), registered attendees can view all of this content for 30 days. But you’ll want to watch these awesome scientists live, preferably with a half-eaten pastry and to-go cup of coffee to simulate the full scientific conference experience.

Did we miss something? Email yaroshc@pennmedicine.upenn.edu.

Talks

Wednesday, June 24

Focus Session: COREdinates Group: Tools for Basic and Applied Stem Cell Technology

Moderated by CHOP’s Deborah French, this session is focused on “best practices” in reprogramming, gene editing, disease modeling, and biobanking. CHOP’s Hyun Hyung (Claire) An will be presenting at 2:15 PM on Using Induced Pluripotent Stem Cells to Improve Transfusion Therapy in Patients with Sickle Cell Disease.

Thursday, June 25

Thursday gets into the heart (and nerve, kidney, etc.) of the schedule with several thematic concurrent sessions. Skip around to catch these presentations:

Concurrent – Cellular Identity: Cardiac and Muscle

Hao Wu– Decoding Human Cardiac Maturation and Aging with Single-Cell Multi-omics Sequencing (11:35 – 11:43 AM)

Concurrent – Clinical Applications: Early Development and Pluripotency — Interspecies chimeras for stem cell research

Qi Qiu- Massively Parallel, Time-Resolved Single-Cell RNA Sequencing with SCNT-SEQ (11:45 – 11:53 AM)

Concurrent – Modeling Development and Disease: Organoids of Endoderm and Kidney

Paul Gadue– A Patient iPSC Line Reveals the Penetrance of Pancreatic Agenesis Caused by GATA6 Mutations is Modified by a Non-Coding SNP (12:05 – 12:13 PM)

Plenary III: Embryogenesis and Development

Along with other field leaders exploring the developmental principles fundamental to all parts of stem cell biology, hear from IRM Director Ken Zaret at 4:25 PM. His talk is titled, “Prospects for Changing Cell Fate at Will.”

Friday, June 26

Concurrent–“Tissue Stem Cells and Regeneration: Neural”

Make sure to tune in for Pantelis Rompolas’ eye-opening talk on “Tissue Wide Coordination of Corneal Homeostasis Revealed at the Single Stem Cell Level by 2-Photon Live Imaging.” (12:05 – 12:13 PM)

Posters

Poster sessions at this year’s ISSCR are built around the same broad themes as the concurrent sessions.  Stop by for the live chats to ask questions and otherwise interact with this talented bunch.

Session I: Thursday, 25 June: 2:00 PM – 4:00 PM EDT

CI319 – PERTURBATION PANEL PROFILING IDENTIFIES TRANSCRIPTION FACTORS THAT ENHANCE DIRECTED CHANGES OF CELL IDENTITY (Ian Mellis)

CI321 – LINEAGE ANALYSIS OF CELLULAR STATES PREDICTING REPROGRAMMING INTO HUMAN INDUCED PLURIPOTENT STEM CELLS (Naveen Jain)

CA265 – REVEALING THE ‘PRIMED’ CELLULAR STATES UNDERLYING VARIABILITY IN FATES FOLLOWING DIRECTED DIFFERENTIATION (Connie Jiang)

THREE researchers from the Raj lab at Penn will be presenting research into cell identity. Make sure to visit them all to learn about how to search for transcription factors underlying cell type, analyze rare cell states, and find populations of cells primed for different fates.

Session II: Thursday, 25 June: 10:00 PM – 12:00 AM EDT

CA196 – COMPARISON OF MITOCHONDRIAL FUNCTION IN EXCITATORY NEURONS FROM SUBJECTS WITH THE 22Q11.2 DELETION SYNDROME WITH AND WITHOUT SCHIZOPHRENIA (Jianping Li)

CI105 – CELL-TYPE-SPECIFIC TRANSCRIPTOME AND CHROMATIN ACCESSIBILITY DYNAMICS IN A MODEL OF HUMAN HEART DEVELOPMENT AND MATURATION (Peng Hu)

Finish the night with some cell-type specific science that will touch both your head and your heart.

Session IV: Friday, 26 June: 2:00 PM – 4:00 PM EDT

MDD147 – INVESTIGATING THE ROLE OF TBX2 AND TBX3 IN HUMAN ENDODERM DEVELOPMENT USING HUMAN PLURIPOTENT STEM CELLS (Matthew George)

MDD184 – HIPSC-DERIVED METABOLIC CELL TYPES REVEAL INDIVIDUAL-SPECIFIC GLUCOCORTICOID DRUG RESPONSE (Wenxiang Hu)

Come by the second Friday poster session for presentations featuring models of development that take advantage of hiPSCs.

Session VI: Saturday, 27 June: 12:00 – 2:00 PM EDT

MDD256 – NEUROINFLAMMATION AND INTEGRATED STRESS RESPONSE SIGNALING PERSIST IN A HUMAN IPSC TRI-CULTURE MODEL OF HIV INFECTION DESPITE ANTIRETROVIRAL TREATMENT (Eugene Mironets)

Finally, end your poster hopping with a stop by this exploration of an all human tri-culture that recapitulates key features of HIV infection in the central nervous system.

Stay connected with IRM@Home

Dear PARS students, PASH students, and other friends:

We miss you!

Social distancing means we can’t meet in person right now, but we don’t have to lose touch! The IRM and our partner organizations will be hosting “IRM@Home” webinars for students during our time away. These session will help you grow your networks and learn even more about biomedical science and careers in STEM. Please mark your calendars for Tuesdays at 10 AM!

How to participate:

  • Visit https://bluejeans.com/687607787 during our scheduled session.
  • Connect to the audio via computer or phone line.
  • Ask questions using the chat function. Type your questions into the box and submit.
  • If you can’t make it, please check back here Tuesday afternoon for information about our recording.

***Please note that this session will be recorded and made publicly available. All participants will have audio and video muted upon entry to the meeting. If you do not consent to having your audio or video recorded, please stay muted. Participants will be able to ask questions using the Bluejeans chat function.

Upcoming IRM@Home recordings

03/31- Heather Butts

 

Join us on Tuesday, March 31 as we welcome back Heather Butts! Heather will be answering your questions about:

  • Essays
  • Applications
  • Interviews
  • and more!

04/07- David Garbe

 

Our April 7 speaker will be David Garbe, Ph.D., Director of Outreach and Education at the Pennsylvania Society for Biomedical Research (PSBR). David develops in-class activities for students like you using the scientific know-how he’s developed over a wide-ranging STEM career. Listen in to hear about his path from Penn graduate student to the pharmaceutical industry and nonprofit sector and learn insights to help you on your own STEM journey!

Previous IRM@Home recordings

Recording link: https://bluejeans.com/s/9b8xh

On March 24, Heather Butts, JD, MPH, MA, Founder of L.E.A.R.N. for Life Consulting and Adjunct Professor at Columbia University School of Public Health and St. John’s University School of Law, joined us. She spoke about how to scout colleges and prepare for applications and answered viewer questions. Click here to view a recording of this session.

2020 Retreat registration now open!

Register now for the IRM’s annual retreat, January 30, 2020 at the Franklin Institute in Philadelphia, PA. Registration is open to all Penn/CHOP faculty, staff, postdocs, and students. Find more information and register here.

 

 

 

Wistar Translational Science Seminar Series, June 12 2019: Rob Dorigatti, Ph.D.

On Wednesday, June 12th, the Wistar Institute will host Rob Dorigatti from Evotec as part of their Translational Science Seminar Series. Dr. Dorgotti will be presenting a seminar on requirements for advancing research discoveries through preclinical development and into the clinic. It should be a useful opportunity to learn more about early stage drug development.
For more information, visit wistar.org.