Take an IRM-guided tour of this week’s meeting with our ISSCR viewer guide.
For the first time ever, the International Society for Stem Cell Research (ISSCR) Annual Meeting will be held virtually, from June 23 to June 27. This year, physical movement and jet lag won’t limit your ability to catch talks and meet new people. However, with so much great stuff happening over the next few days, it’s easy to feel overwhelmed.
Let us help you with that. Below is an “ISSCR viewer guide” featuring talks and posters from University of Pennsylvania and Children’s Hospital of Philadelphia (CHOP) researchers.
PRO TIP: While this guide sorts everything by day and time (Eastern Daylight Time for Philly folks), registered attendees can view all of this content for 30 days. But you’ll want to watch these awesome scientists live, preferably with a half-eaten pastry and to-go cup of coffee to simulate the full scientific conference experience.
Did we miss something? Email yaroshc@pennmedicine.upenn.edu.
Talks
Wednesday, June 24
Focus Session: COREdinates Group: Tools for Basic and Applied Stem Cell Technology
Moderated by CHOP’s Deborah French, this session is focused on “best practices” in reprogramming, gene editing, disease modeling, and biobanking. CHOP’s Hyun Hyung (Claire) An will be presenting at 2:15 PM on Using Induced Pluripotent Stem Cells to Improve Transfusion Therapy in Patients with Sickle Cell Disease.
Thursday, June 25
Thursday gets into the heart (and nerve, kidney, etc.) of the schedule with several thematic concurrent sessions. Skip around to catch these presentations:
Concurrent – Cellular Identity: Cardiac and Muscle
Hao Wu– Decoding Human Cardiac Maturation and Aging with Single-Cell Multi-omics Sequencing (11:35 – 11:43 AM)
Concurrent – Clinical Applications: Early Development and Pluripotency — Interspecies chimeras for stem cell research
Qi Qiu- Massively Parallel, Time-Resolved Single-Cell RNA Sequencing with SCNT-SEQ (11:45 – 11:53 AM)
Concurrent – Modeling Development and Disease: Organoids of Endoderm and Kidney
Paul Gadue– A Patient iPSC Line Reveals the Penetrance of Pancreatic Agenesis Caused by GATA6 Mutations is Modified by a Non-Coding SNP (12:05 – 12:13 PM)
Plenary III: Embryogenesis and Development
Along with other field leaders exploring the developmental principles fundamental to all parts of stem cell biology, hear from IRM Director Ken Zaret at 4:25 PM. His talk is titled, “Prospects for Changing Cell Fate at Will.”
Friday, June 26
Concurrent–“Tissue Stem Cells and Regeneration: Neural”
Make sure to tune in for Pantelis Rompolas’ eye-opening talk on “Tissue Wide Coordination of Corneal Homeostasis Revealed at the Single Stem Cell Level by 2-Photon Live Imaging.” (12:05 – 12:13 PM)
Posters
Poster sessions at this year’s ISSCR are built around the same broad themes as the concurrent sessions. Stop by for the live chats to ask questions and otherwise interact with this talented bunch.
Session I: Thursday, 25 June: 2:00 PM – 4:00 PM EDT
CI319 – PERTURBATION PANEL PROFILING IDENTIFIES TRANSCRIPTION FACTORS THAT ENHANCE DIRECTED CHANGES OF CELL IDENTITY (Ian Mellis)
CI321 – LINEAGE ANALYSIS OF CELLULAR STATES PREDICTING REPROGRAMMING INTO HUMAN INDUCED PLURIPOTENT STEM CELLS (Naveen Jain)
CA265 – REVEALING THE ‘PRIMED’ CELLULAR STATES UNDERLYING VARIABILITY IN FATES FOLLOWING DIRECTED DIFFERENTIATION (Connie Jiang)
THREE researchers from the Raj lab at Penn will be presenting research into cell identity. Make sure to visit them all to learn about how to search for transcription factors underlying cell type, analyze rare cell states, and find populations of cells primed for different fates.
Session II: Thursday, 25 June: 10:00 PM – 12:00 AM EDT
CA196 – COMPARISON OF MITOCHONDRIAL FUNCTION IN EXCITATORY NEURONS FROM SUBJECTS WITH THE 22Q11.2 DELETION SYNDROME WITH AND WITHOUT SCHIZOPHRENIA (Jianping Li)
CI105 – CELL-TYPE-SPECIFIC TRANSCRIPTOME AND CHROMATIN ACCESSIBILITY DYNAMICS IN A MODEL OF HUMAN HEART DEVELOPMENT AND MATURATION (Peng Hu)
Finish the night with some cell-type specific science that will touch both your head and your heart.
Session IV: Friday, 26 June: 2:00 PM – 4:00 PM EDT
MDD147 – INVESTIGATING THE ROLE OF TBX2 AND TBX3 IN HUMAN ENDODERM DEVELOPMENT USING HUMAN PLURIPOTENT STEM CELLS (Matthew George)
MDD184 – HIPSC-DERIVED METABOLIC CELL TYPES REVEAL INDIVIDUAL-SPECIFIC GLUCOCORTICOID DRUG RESPONSE (Wenxiang Hu)
Come by the second Friday poster session for presentations featuring models of development that take advantage of hiPSCs.
Session VI: Saturday, 27 June: 12:00 – 2:00 PM EDT
MDD256 – NEUROINFLAMMATION AND INTEGRATED STRESS RESPONSE SIGNALING PERSIST IN A HUMAN IPSC TRI-CULTURE MODEL OF HIV INFECTION DESPITE ANTIRETROVIRAL TREATMENT (Eugene Mironets)
Finally, end your poster hopping with a stop by this exploration of an all human tri-culture that recapitulates key features of HIV infection in the central nervous system.