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Discovery of Molecular Signatures of Immature Neurons in The Human Brain Throughout Life Provide New Insights into Brain Plasticity and Other Functions

A team led by researchers at the Perelman School of Medicine at the University of Pennsylvania has used advanced techniques to show that, in a key memory region of the brain called the hippocampus, immature, plastic neurons are present in significant numbers throughout the human lifespan. The findings, published this month in Nature, hope to … Continue reading Discovery of Molecular Signatures of Immature Neurons in The Human Brain Throughout Life Provide New Insights into Brain Plasticity and Other Functions

IRM Director Ken Zaret elected as Associate Member of EMBO

For his contributions to the life sciences, IRM Director Ken Zaret was recently elected as an Associate Member of the European Molecular Biology Organization (EMBO). This lifelong honor was bestowed on Dr. Zaret and 66 groundbreaking scientists following nomination and selection by existing EMBO members. EMBO Members provide guidance and support for EMBO activities, for … Continue reading IRM Director Ken Zaret elected as Associate Member of EMBO

A newly identified stem cell regulator enables lifelong sperm production

Unlike women, who are born with all the eggs they’ll ever have, men can continue to produce sperm throughout their adult lives. To do so, they require a constant renewal of spermatogonial stem cells, which give rise to sperm. This reinvigoration of stem cells depends on a newly characterized stem cell self-renewal factor called DOT1L, … Continue reading A newly identified stem cell regulator enables lifelong sperm production

Experimenting with stem cells at the bench

Working to find cellular cures for diseases.

The IRM supports initiatives to translate discoveries in stem cell science into new therapies. We offer:

  • Collaborative Research Programs
  • Grants for Innovative Ideas
  • Engaging Symposiums & Events
  • Training Workshops
  • Award-winning Outreach Partnerships
  • Scientific Communication Support

Research Programs

Epithelial Stem Cells

The cells that constitute our skin and line our organs are the first line of defense against injury and illness. These vital barriers are replenished by epithelial stem cells. IRM researchers study epithelial stem cells throughout the body to find ways to improve wound healing, heal the lungs after viral infection, reverse baldness, and more. … Continue reading Epithelial Stem Cells

Hematopoietic Stem Cells

Humans produce hundreds of billions of blood cells every day, thanks to the incredible regenerative potential of hematopoietic stem cells (HSCs). To create all those oxygen-carrying red blood cells and pathogen-fighting white blood cells, HSCs follow very specific development pathways. IRM researchers are exploring how to control these pathways and use HSCs to treat disease. … Continue reading Hematopoietic Stem Cells

Musculoskeletal Regeneration

Muscles, bones, and cartilage are critical to our quality of life, so maintaining musculoskeletal health from childhood to old age is incredibly important. However, injuries, aging, and disease can all undermine musculoskeletal health. IRM scientists and engineers are studying innovative ways to repair degraded tissues and are working toward solutions for muscular dystrophy, osteoarthritis, and … Continue reading Musculoskeletal Regeneration

Neurodevelopment & Regeneration

The nervous system’s capacity for growth and change underlies everything from proper mental development to the body’s coordination and movement. IRM researchers study how neurons develop in different stages of life, why the neurons in limbs regenerate better than in the brain, and how dysregulation leads to diseases including autism spectrum disorder, schizophrenia, and glioblastoma. … Continue reading Neurodevelopment & Regeneration

Reproductive Medicine

The cells of the reproductive system give rise to all other cells in the body. IRM researchers seek to understand the regenerative qualities of sperm and eggs and the biology of early embryos, with the goals of improving the storage of germ cells and embryos for cancer patients and creating safe, effective assisted reproductive technologies. … Continue reading Reproductive Medicine

Outreach

Sharing our science across the Philadelphia region and beyond.