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Join us on the third Wednesday of every month for Stem Cel Club. Click here to view our calendar.

Recent News

The immune link between a leaky blood-brain barrier and schizophrenia

Like a stern bodyguard for the central nervous sytem, the blood-brain barrier keeps out anything that could lead to disease and dangerous inflammation—at least when all is functioning normally. That may not be the case in people with schizophrenia and other mental disorders, suggest new findings from a team led by researchers from the School … Continue reading The immune link between a leaky blood-brain barrier and schizophrenia

Arcuate organoids to study development and disease of the hypothalamus

Human brain organoids are remarkable platforms for modeling features of human brain development and diseases. Building on methods to generate organoids to model different brain regions such as the cortex and the midbrain, researchers at the Perelman School of Medicine at the University of Pennsylvania have generated the first organoids of the arcuate nucleus (ARC), … Continue reading Arcuate organoids to study development and disease of the hypothalamus

New research uncovers distinct roles for corneal stem cells

How does the cornea maintain its rapid pace of cell turnover—and how does the body regenerate it after injury? A research team led by Pantelis Rompolas, Assistant Professor of Dermatology and Olivia Farrelly, a Ph.D. candidate in the Cell and Molecular Biology Graduate Group, uncovered exciting new clues by identifying separate stem cell pools for … Continue reading New research uncovers distinct roles for corneal stem cells

Experimenting with stem cells at the bench

Working to find cellular cures for diseases.

The IRM supports initiatives to translate discoveries in stem cell science into new therapies. We offer:

  • Collaborative Research Programs
  • Grants for Innovative Ideas
  • Engaging Symposiums & Events
  • Training Workshops
  • Award-winning Outreach Partnerships
  • Scientific Communication Support

Research Programs

Epithelial Stem Cells

The cells that constitute our skin and line our organs are the first line of defense against injury and illness. These vital barriers are replenished by epithelial stem cells. IRM researchers study epithelial stem cells throughout the body to find ways to improve wound healing, heal the lungs after viral infection, reverse baldness, and more. … Continue reading Epithelial Stem Cells

Hematopoietic Stem Cells

Humans produce hundreds of billions of blood cells every day, thanks to the incredible regenerative potential of hematopoietic stem cells (HSCs). To create all those oxygen-carrying red blood cells and pathogen-fighting white blood cells, HSCs follow very specific development pathways. IRM researchers are exploring how to control these pathways and use HSCs to treat disease. … Continue reading Hematopoietic Stem Cells

Musculoskeletal Regeneration

Muscles, bones, and cartilage are critical to our quality of life, so maintaining musculoskeletal health from childhood to old age is incredibly important. However, injuries, aging, and disease can all undermine musculoskeletal health. IRM scientists and engineers are studying innovative ways to repair degraded tissues and are working toward solutions for muscular dystrophy, osteoarthritis, and … Continue reading Musculoskeletal Regeneration

Neurodevelopment & Regeneration

The nervous system’s capacity for growth and change underlies everything from proper mental development to the body’s coordination and movement. IRM researchers study how neurons develop in different stages of life, why the neurons in limbs regenerate better than in the brain, and how dysregulation leads to diseases including autism spectrum disorder, schizophrenia, and glioblastoma. … Continue reading Neurodevelopment & Regeneration

Reproductive Medicine

The cells of the reproductive system give rise to all other cells in the body. IRM researchers seek to understand the regenerative qualities of sperm and eggs and the biology of early embryos, with the goals of improving the storage of germ cells and embryos for cancer patients and creating safe, effective assisted reproductive technologies. … Continue reading Reproductive Medicine

Outreach

Sharing our science across the Philadelphia region and beyond.