Recent News

IRM Awards 3rd Elaine Redding Brinster Prize to Stuart Orkin, MD

Recognized for landmark discoveries of the molecular basis of blood disorders and using the basic science findings for therapeutic approaches, the Institute for Regenerative Medicine at the University of Pennsylvania has awarded Stuart H. Orkin, MD the third Elaine Redding Brinster Prize in Science or Medicine. He elucidated the mechanism controlling the switch from fetal to adult hemoglobin, … Continue reading IRM Awards 3rd Elaine Redding Brinster Prize to Stuart Orkin, MD

Andrew Modzelewski, PhD: recipient 2023 Arnold and Mabel Beckman Foundation Award

Congratulations to IRM faculty, Andrew Modzelewski, PhD for being an award recipient as part of the 2023 Beckman Young Investigator Program. The Beckman Young Investigator (BYI) Program provides research support to the most promising young faculty members in the early stages of their academic careers in the chemical and life sciences, particularly to foster the … Continue reading Andrew Modzelewski, PhD: recipient 2023 Arnold and Mabel Beckman Foundation Award

Modeling development using hydrogels

    A team of researchers including Robert Mauck, PhD, the Mary Black Ralston Professor of Orthopaedic Surgery and Professor of Bioengineering at the University of Pennsylvania recently covered how engineered hydrogels can serve as in vitro culture platforms to present such signals in a controlled manner and include examples of how they have been … Continue reading Modeling development using hydrogels

Experimenting with stem cells at the bench

Working to find cellular cures for diseases.

The IRM supports initiatives to translate discoveries in stem cell science into new therapies. We offer:

  • Collaborative Research Programs
  • Grants for Innovative Ideas
  • Engaging Symposiums & Events
  • Training Workshops
  • Award-winning Outreach Partnerships
  • Scientific Communication Support

Research Programs

Epithelial Stem Cells

The cells that constitute our skin and line our organs are the first line of defense against injury and illness. These vital barriers are replenished by epithelial stem cells. IRM researchers study epithelial stem cells throughout the body to find ways to improve wound healing, heal the lungs after viral infection, reverse baldness, and more. The Epithelial Stem Cells IRM Program focuses on the pathways the give rise … Continue reading Epithelial Stem Cells

Hematopoietic Stem Cells

Humans produce hundreds of billions of blood cells every day, thanks to the incredible regenerative potential of hematopoietic stem cells (HSCs). To create all those oxygen-carrying red blood cells and pathogen-fighting white blood cells, HSCs follow very specific development pathways. IRM researchers are exploring how to control these pathways and use HSCs to treat disease. … Continue reading Hematopoietic Stem Cells

Musculoskeletal Regeneration

Muscles, bones, tendons, cartilage, and ligaments are critical to maintaining our quality of life. As such, methodologies to support proper musculoskeletal health from childhood to old age are incredibly important. Unfortunately, injuries, aging, and disease of musculoskeletal tissues are common and become more frequent with aging, resulting in a tremendous socioeconomic burden. IRM scientists and … Continue reading Musculoskeletal Regeneration

Neurodevelopment & Regeneration

The nervous system’s capacity for growth and change underlies everything from proper mental development to the body’s coordination and movement. IRM researchers study how neurons develop in different stages of life, why the neurons in limbs regenerate better than in the brain, and how dysregulation leads to diseases including autism spectrum disorder, schizophrenia, and glioblastoma. … Continue reading Neurodevelopment & Regeneration

Reproductive Medicine

The cells of the reproductive system give rise to all other cells in the body. IRM researchers seek to understand the regenerative qualities of sperm and eggs and the biology of early embryos, with the goals of improving the storage of germ cells and embryos for cancer patients and creating safe, effective assisted reproductive technologies. … Continue reading Reproductive Medicine


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