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Frozen testicular tissue still viable after 20 years

The rate of survival for childhood cancers has increased dramatically in the last several decades, but a serious side effect of treatment is diminished fertility later in life. A potential treatment for boys facing cancer treatment would be to harvest, freeze, and, after the cancer is cured, reimplant their testicular tissue, which contains stem cells … Continue reading Frozen testicular tissue still viable after 20 years

Kate Hamilton wins American Physiological Society GI/Liver New Investigator Award

Kathryn (Kate) Hamilton, Assistant Professor of Pediatrics and Co-Director of the Children’s Hospital of Philadelphia’s Gastrointestinal Epithelium Modeling Program, has been awarded the 2022 Gastrointestinal & Liver Physiology Section New Investigator Award by the American Physiological Society (APS)! She accepted the award at this month’s Experimental Biology Annual Meeting in Philadelphia. Kate’s team studies the … Continue reading Kate Hamilton wins American Physiological Society GI/Liver New Investigator Award

Piezo1 Possible Key to Supporting Muscle Regeneration in Duchenne Muscular Dystrophy

One protein, Piezo1, is key to marshalling muscle stem cells’ unique shapes and response to injuries, but it is in low supply in those with Duchenne muscular dystrophy, according to a team at the Perelman School of Medicine at the University of Pennsylvania. However, when they re-activated Piezo1, it allowed muscle stem cells in mice … Continue reading Piezo1 Possible Key to Supporting Muscle Regeneration in Duchenne Muscular Dystrophy

Experimenting with stem cells at the bench

Working to find cellular cures for diseases.

The IRM supports initiatives to translate discoveries in stem cell science into new therapies. We offer:

  • Collaborative Research Programs
  • Grants for Innovative Ideas
  • Engaging Symposiums & Events
  • Training Workshops
  • Award-winning Outreach Partnerships
  • Scientific Communication Support

Research Programs

Epithelial Stem Cells

The cells that constitute our skin and line our organs are the first line of defense against injury and illness. These vital barriers are replenished by epithelial stem cells. IRM researchers study epithelial stem cells throughout the body to find ways to improve wound healing, heal the lungs after viral infection, reverse baldness, and more. … Continue reading Epithelial Stem Cells

Hematopoietic Stem Cells

Humans produce hundreds of billions of blood cells every day, thanks to the incredible regenerative potential of hematopoietic stem cells (HSCs). To create all those oxygen-carrying red blood cells and pathogen-fighting white blood cells, HSCs follow very specific development pathways. IRM researchers are exploring how to control these pathways and use HSCs to treat disease. … Continue reading Hematopoietic Stem Cells

Musculoskeletal Regeneration

Muscles, bones, and cartilage are critical to our quality of life, so maintaining musculoskeletal health from childhood to old age is incredibly important. However, injuries, aging, and disease can all undermine musculoskeletal health. IRM scientists and engineers are studying innovative ways to repair degraded tissues and are working toward solutions for muscular dystrophy, osteoarthritis, and … Continue reading Musculoskeletal Regeneration

Neurodevelopment & Regeneration

The nervous system’s capacity for growth and change underlies everything from proper mental development to the body’s coordination and movement. IRM researchers study how neurons develop in different stages of life, why the neurons in limbs regenerate better than in the brain, and how dysregulation leads to diseases including autism spectrum disorder, schizophrenia, and glioblastoma. … Continue reading Neurodevelopment & Regeneration

Reproductive Medicine

The cells of the reproductive system give rise to all other cells in the body. IRM researchers seek to understand the regenerative qualities of sperm and eggs and the biology of early embryos, with the goals of improving the storage of germ cells and embryos for cancer patients and creating safe, effective assisted reproductive technologies. … Continue reading Reproductive Medicine

Outreach

Sharing our science across the Philadelphia region and beyond.