Our Research

Our researchers study how stem cells function, regenerate, and differentiate. We use those insights to model diseases and find ways to repair, rebuild, and replace broken body systems.

How do we approach science?

To achieve our mission of turning cells and tissues into medicines, the IRM encourages collaborations across different fields of biology, engineering, and medicine. Our researchers study life from the early embryo to old age to understand how stem cells interpret signals and “make decisions” that result in healthy tissues. Armed with this information, IRM scientists and engineers are creating strategies for new therapies, diagnostics, and medical devices.


Programs of Emphasis

Solving challenges in regenerative science and medicine takes teamwork. The IRM sponsors five standing programs to encourage interdisciplinary collaborations focused on key cells types and body systems:


New Frontiers

Our researchers are always exploring new ideas that cross between or go beyond our core programs. This diversity enriches our IRM community and pushes our science in exciting directions. Some examples include:

  • Combining imaging techniques and CRISPR to track COVID-19 infection in cells
  • Creating pateint-derived organoids and engineering organs-on-chips for improved testing and diagnostics
  • Using advanced technologies to examine single cells to learn how they choose their fates

To help kindle these sparks, we offers grants for innovative ideas and new collaborations. If you’re a Penn, CHOP, or Wistar researcher interested in collaborating with IRM faculty or applying for funding opportunities, please join us.