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Author yaroshc Categories News

Kate Hamilton wins American Physiological Society GI/Liver New Investigator Award

Kathryn (Kate) Hamilton, Assistant Professor of Pediatrics and Co-Director of the Children’s Hospital of Philadelphia’s Gastrointestinal Epithelium Modeling Program, has been awarded the 2022 Gastrointestinal & Liver Physiology Section New Investigator Award by the American Physiological Society (APS)! She accepted the award at this month’s Experimental Biology Annual Meeting in Philadelphia.

Kate’s team studies the role of RNA-binding proteins in regulating epithelial cell fate and function in the gastrointestinal tract. APS recognized her for this award following a competitive selection process based on external nominations from leaders in this field of study.

Congratulations Kate!

 

 

Author yaroshc Categories News, Research

Piezo1 Possible Key to Supporting Muscle Regeneration in Duchenne Muscular Dystrophy

One protein, Piezo1, is key to marshalling muscle stem cells’ unique shapes and response to injuries, but it is in low supply in those with Duchenne muscular dystrophy, according to a team at the Perelman School of Medicine at the University of Pennsylvania. However, when they re-activated Piezo1, it allowed muscle stem cells in mice to return to their normal, distinctly-shaped states so that they could repair broken down, dystrophic muscles. These findings, published in Science Advances, open the door to potential molecular-level treatments that may slow or even halt the progression of muscular dystrophy.

“We showed that muscle stem cells have a variety of extensions that are used to sense their environment to respond to injuries, all of which is controlled by the protein Piezo1,” said the study’s lead author, Foteini Mourkioti, PhD, an assistant professor of Orthopaedic Surgery. “This is in contrast to previous belief, which considered muscle stem cells to be simply round and dormant in undamaged muscles.”

Read more about this research in Penn Medicine News.

Author yaroshc Categories News

Jennifer Phillips-Cremins wins ISSCR’s Dr. Susan Lim Award for Outstanding Young Investigator

Jennifer E. Phillips-Cremins has been awarded the 2022 Dr. Susan Lim Award for Outstanding Young Investigator by the International Society for Stem Cell Research (ISSCR).

The prize recognizes the exceptional achievements of an investigator in the early part of his or her independent career in stem cell research. Dr. Phillips-Cremins is being recognized for pioneering research toward understanding how chromatin works through long-range mechanisms to govern stem cell differentiation into neurons and neural circuits.

Read more about her work and the Dr. Susan Lim Award on ISSCR’s website.

Author yaroshc Categories News, Research

Penn research shows origin of rare disease FOP rooted in muscle regeneration dysfunction

Fibrodysplasia ossificans progressiva (FOP) is a rare disease characterized by extensive bone growth outside of the normal skeleton that pre-empts the body’s normal responses to even minor injuries. It results in what some term a “second skeleton,” which locks up joint movement and could make it hard to breathe. However, new research in mice by a team at the Perelman School of Medicine at the University of Pennsylvania shows that forming extra-skeletal bone might not be the only driver of the disease. Impaired and inefficient muscle tissue regeneration appears to open the door for unwanted bone to form in areas where new muscle should occur after injuries. This discovery opens up the possibility of pursuing new therapies for FOP and was published today in NPJ Regenerative Medicine.

“While we have made great strides toward better understanding this disease, this work shows how basic biology can provide great insights into appropriate regenerative medicine therapies,” said the study’s lead author, Foteini Mourkioti, PhD, an assistant professor of Orthopaedic Surgery and Cell and Developmental Biology, as well as the co-director of the Penn Institute for Regenerative Medicine, Musculoskeletal Program. “From the lab, we’re now able to show that there is potential for a whole new realm of therapies for patients with this devastating condition.”

Read more about this research in Penn Medicine News.

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